Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 193-202 , February 2006

Brain SPECT imaging and whole-body biodistribution with [123I]ADAM — a serotonin transporter radiotracer in healthy human subjects

  • Kun-Ju Lin

      Affiliations

    • Graduate Institute of Clinical Medical Sciences, Chang-Gung University, Tao-Yuan 333, Taiwan
    • Molecular Imaging Center, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • Department of Nuclear Medicine, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • ,
  • Chia-Yih Liu

      Affiliations

    • Neuroscience Research Center, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • Department of Psychiatry, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • ,
  • Shiaw-Pyng Wey

      Affiliations

    • Molecular Imaging Center, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • Department of Medical Imaging and Radiological Sciences, Chang-Gung University, Tao-Yuan 333, Taiwan
    • ,
  • Ing-Tsung Hsiao

      Affiliations

    • Molecular Imaging Center, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • Department of Medical Imaging and Radiological Sciences, Chang-Gung University, Tao-Yuan 333, Taiwan
    • ,
  • Jay Wu

      Affiliations

    • Health Physics Divisions, Atomic Energy Council, Institute of Nuclear Energy Research, Tao-Yuan 325, Taiwan
    • ,
  • Ying-Kai Fu

      Affiliations

    • Atomic Energy Council, Institute of Nuclear Energy Research, Tao-Yuan 325, Taiwan
    • ,
  • Tzu-Chen Yen

      Affiliations

    • Molecular Imaging Center, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • Department of Nuclear Medicine, Chang-Gung Memorial Hospital, Tao-Yuan 333, Taiwan
    • Corresponding Author InformationCorresponding author. Department of Nuclear Medicine, Chang-Gung Memorial Hospital, Tao-Yuan, Taiwan. Tel.: +886 3 3281200x2673; fax: +886 3 3280267.

Received 8 July 2005 ,Revised 16 September 2005 ,Accepted 12 October 2005.

References 

  1. Tejanibutt SM, Yang JX, Pawlyk AC. Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus. Neuroreport. 1995;6:1207–1210
  2. Malhotra AK, Goldman D, Mazzanti C, Clifton A, Breier A, Pickar D. A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics. Mol Psychiatry. 1998;3:328–332
  3. Kuikka J, Tammela L, Rissanen A, Bergstrom K, Muhonen M, Vanninen E, et al. Altered serotonin transporter density in obese binge eating women: initial findings. Eur J Nucl Med Mol Imaging. 2000;27:S90
  4. Stengler-Wenzke K, Muller U, Angermeyer MC, Sabri O, Hesse S. Reduced serotonin transporter-availability in obsessive–compulsive disorder (OCD). Eur Arch Psychiatry Clin Neurosci. 2004;254:252–255
  5. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, et al. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet. 1996;347:731–733
  6. Owens MJ, Nemeroff CB. Role of serotonin in the pathophysiology of depression — focus on the serotonin transporter. Clin Chem. 1994;40:288–295
  7. Wolf WA, Kuhn DM. Modulation of serotonin release. Interactions between the serotonin transporter and autoreceptors. Ann N Y Acad Sci. 1990;604:505–513
  8. Arango V, Underwood MD, Mann JJ. Serotonin brain circuits involved in major depression and suicide. Prog Brain Res. 2002;136:443–453
  9. Arango V, Underwood MD, Mann JJ. Postmortem findings in suicide victims — implications for in vivo imaging studies. Ann N Y Acad Sci. 1997;836:269–287
  10. Hiltunen J, Akerman KK, Kuikka JT, Bergstrom KA, Halldin C, Nikula T, et al. Iodine-123 labeled nor-beta-CIT as a potential tracer for serotonin transporter imaging in the human brain with single-photon emission tomography. Eur J Nucl Med Mol Imaging. 1998;25:19–23
  11. Houle S, Ginovart N, Hussey D, Meyer JH, Wilson AA. Imaging the serotonin transporter with positron emission tomography: initial human studies with [C-11]DAPP and [C-11]DASB. Eur J Nucl Med Mol Imaging. 2000;27:1719–1722
  12. Baldwin RM, Zeaponce Y, Zoghbi SS, Laurelle M, Altikriti MS, Sybirska EH, et al. Evaluation of the monoamine uptake site ligand [I-123] methyl 3-beta-(4-iodophenyl)-tropane-2-beta-carboxylate ([I-123]beta-CIT) in nonhuman-primates — pharmacokinetics, biodistribution and SPECT brain imaging coregistered with MRI. Nucl Med Biol. 1993;20:597–606
  13. Scheffel U, Dannals RF, Cline EJ, Ricaurte GA, Carroll FI, Abraham P, et al. [I-123-125I]RTI-55, an in vivo label for the serotonin transporter. Synapse. 1992;11:134–139
  14. Brucke T, Kornhuber J, Angelberger P, Asenbaum S, Frassine H, Podreka I. SPECT imaging of dopamine and serotonin transporters with [123I]beta-CIT. Binding kinetics in the human brain. J Neural Transm Gen Sect. 1993;94(2):137–146
  15. Fujita M, Takatoku K, Matoba Y, Nishiura M, Kobayashi K, Inoue O, et al. Differential kinetics of [I-123]beta-CIT binding to dopamine and serotonin transporters. Eur J Nucl Med Mol Imaging. 1996;23:431–436
  16. Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G, et al. Biodistribution study of [(123)I] ADAM in mice: correlation with whole body autoradiography. Nucl Med Biol. 2002;29:643–650
  17. Lin KJ, Yen TC, Wey SP, Hwang JJ, Ye XX, Tzen KY, et al. Characterization of the binding sites for I-123-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. J Nucl Med. 2004;45:673–681
  18. Oya S, Choi SR, Hou C, Mu M, Kung MP, Acton PD, et al. 2-(2-((Dimethylamino)methyl)phenyl)thio-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol. 2000;27:249–254
  19. Huang WS, Ma KH, Cheng CY, Chen CY, Fu YK, Chou YH, et al. Imaging serotonin transporters with [123I]ADAM brain SPECT in healthy non-human primates. Nucl Med Commun. 2004;25:515–519
  20. Acton PD, Choi SR, Hou C, Plossl K, Kung HF. Quantification of serotonin transporters in nonhuman primates using [(123)I]ADAM and SPECT. J Nucl Med. 2001;42:1556–1562
  21. Newberg AB, Plossl K, Mozley PD, Stubbs JB, Wintering N, Udeshi M, et al. Biodistribution and imaging with I-123-ADAM: a serotonin transporter imaging agent. J Nucl Med. 2004;45:834–841
  22. Kauppinen TA, Bergstrom KA, Heikman P, Hiltunen J, Ahonen AK. Biodistribution and radiation dosimetry of [I-123]ADAM in healthy human subjects: preliminary results. Eur J Nucl Med Mol Imaging. 2003;30:132–136
  23. Kish SJ, Furukawa Y, Chang LJ, Tong JC, Ginovart N, Wilson A, et al. Regional distribution of serotonin transporter protein in postmortem human brain — is the cerebellum a SERT-free brain region?. Nucl Med Biol. 2005;32:123–128
  24. Varnas K, Halldin C, Hall H. Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum Brain Mapp. 2004;22:246–260
  25. Szabo Z, Kao PF, Scheffel U, Suehiro M, Mathews WB, Ravert HT, et al. Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)McN5652. Synapse. 1995;20:37–43
  26. Szabo Z, Scheffel U, Mathews WB, Ravert HT, Szabo K, Kraut M, et al. Kinetic analysis of [C-11]McN5652: a serotonin transporter radioligand. J Cereb Blood Flow Metab. 1999;19:967–981
  27. Ferrant A, Cauwe F. Quantitative organ-uptake measurement with a gamma camera. Eur J Nucl Med. 1979;4:223–229
  28. Suhara T, Sudo Y, Yoshida K, Okubo Y, Fukuda H, Obata T, et al. Lung as reservoir for antidepressants in pharmacokinetic drug interactions. Lancet. 1998;351:332–335
  29. Ueda M, Iida Y, Mukai T, Mamede M, Ishizu K, Ogawa M, et al. 5-[123I]Iodo-A-85380: assessment of pharmacological safety, radiation dosimetry and SPECT imaging of brain nicotinic receptors in healthy human subjects. Ann Nucl Med. 2004;18:337–344
  30. Lahorte CM, Bacher K, Burvenich I, Coene ED, Cuvelier C, De PC, et al. Radiolabeling, biodistribution, and dosimetry of (123)I-mAb 14C5: a new mAb for radioimmunodetection of tumor growth and metastasis in vivo. J Nucl Med. 2004;45:1065–1073
  31. Fujita M, Seibyl JP, Vaupel DB, Tamagnan G, Early M, Zoghbi SS, et al. Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects. Eur J Nucl Med Mol Imaging. 2002;29:183–190
  32. Schmidt D, Langen KJ, Herzog H, Wirths J, Holschbach M, Kiwit JC, et al. Whole-body kinetics and dosimetry of l-3-123I-iodo-alpha-methyltyrosine. Eur J Nucl Med. 1997;24:1162–1166

PII: S0969-8051(05)00267-2

doi: 10.1016/j.nucmedbio.2005.10.006

Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 193-202 , February 2006

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