Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 21-27, January 2006

Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression

  • Yuji Kuge

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 75 753 4608; fax: +81 75 753 4568.
    • ,
  • Yumiko Katada

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • ,
  • Sayaka Shimonaka

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • ,
  • Takashi Temma

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • ,
  • Hiroyuki Kimura

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
    • ,
  • Yasushi Kiyono

      Affiliations

    • Radioisotopes Research Laboratory, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto 606-8507, Japan
    • ,
  • Chiaki Yokota

      Affiliations

    • Cerebrovascular Laboratory, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan
    • ,
  • Kazuo Minematsu

      Affiliations

    • Cerebrovascular Division, Department of Medicine, National Cardiovascular Center Research Institute, Osaka 565-8565, Japan
    • ,
  • Koh-ichi Seki

      Affiliations

    • Central Institute of Isotope Science, Hokkaido University, Hokkaido 060-8638, Japan
    • ,
  • Nagara Tamaki

      Affiliations

    • Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido 060-8638, Japan
    • ,
  • Kazue Ohkura

      Affiliations

    • Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido 061-0293, Japan
    • ,
  • Hideo Saji

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan

Received 26 August 2005; received in revised form 30 September 2005; accepted 5 October 2005.

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PII: S0969-8051(05)00265-9

doi:10.1016/j.nucmedbio.2005.10.004

Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 21-27, January 2006

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