« Previous
Next »
Nuclear Medicine and Biology
Volume 33, Issue 2
, Pages 185-191
, February 2006
Brain kinetics of the new selective serotonin transporter tracer [123I]ADAM in healthy young adults
References
- Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors. Biol Psychiatry. 2004;56:497–502
- . Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography. Biol Psychiatry. 2004;55:217–224
- Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. Arch Gen Psychiatry. 2004;61:1271–1279
- Reduced serotonin type 1A receptor binding in panic disorder. J Neurosci. 2004;24:589–591
- 123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. J Nucl Med. 2005;46:973–977
- Positron emission tomography of striatal serotonin transporters in Parkinson disease. Arch Neurol. 2003;60:1223–1229
- . Positron emission tomographic evidence of toxic effect of MDMA (“Ecstasy”) on brain serotonin neurons in human beings. Lancet. 1998;352:1433–1437
- Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons. Lancet. 2001;358:1864–1869
- Positron emission tomography imaging of serotonin transporters in the human brain using [11C](+)McN5652. Synapse. 1995;20:37–43
- Comparative evaluation in nonhuman primates of five PET radiotracers for imaging the serotonin transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. J Cereb Blood Flow Metab. 2002;22:1377–1398
- N,N-Dimethyl-2-(2-amino-4-18F-fluorophenylthio)-benzylamine (4-18F-ADAM): an improved PET radioligand for serotonin transporters. J Nucl Med. 2003;44:1890–1897
- SPECT imaging of dopamine and serotonin transporters with [123I]β-CIT: pharmacological characterization of brain uptake in nonhuman primates. Synapse. 1993;13:295–309
- Imaging serotonin and dopamine transporters with 123I-β-CIT SPECT: binding kinetics and effects of normal aging. J Nucl Med. 2000;41:36–44
- . Iodine-123 labelled nor-β-CIT binds to the serotonin transporter in vivo as assessed by biodistribution studies in rats. Eur J Nucl Med. 1998;25:1666–1669
- Age-related decline in central serotonin transporter availability with [123I]β-CIT SPECT. Neurobiol Aging. 2000;21:497–501
- 2-((2-((Dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nucl Med Biol. 2000;27:249–254
- ADAM is an effective tool for in vivo study of serotonergic function: validation in rat models. Synapse. 2004;52:136–142
- Selective in vitro and in vivo binding of [125I]ADAM to serotonin transporters in rat brain. Synapse. 2000;38:403–412
- Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nucl Med Biol. 2004;31:557–562
- . Quantification of serotonin transporters in nonhuman primates using [123I]ADAM and SPECT. J Nucl Med. 2001;42:1556–1562
- Biodistribution and imaging with 123I-ADAM: a serotonin transporter imaging agent. J Nucl Med. 2004;45:834–841
- . Biodistribution an radiation dosimetry of [123I]ADAM in healthy human subjects: preliminary results. Eur J Nucl Med Mol Imaging. 2003;30:132–136
- SPECT of Serotonin Transporters Using 123I-ADAM: optimal imaging time after bolus injection and long-term test–retest in healthy volunteers. J Nucl Med. 2005;46:1301–1309
- . Evaluation of the serotonin transporter ligand [123I]ADAM for SPECT studies in humans. [abstract] Eur J Nucl Med Mol Imaging. 2004;31:S288
- [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labelling in early and advanced Parkinson's disease. J Neurol Neurosurg Psychiatry. 1997;62:133–140
- . Measuring serotonin transporters with [123I]β-CIT SPECT: a double-blind, placebo-controlled, crossover validation study with the selective serotonin reuptake inhibitor citalopram. Neuropsychopharmacology. 2005;30:996–1005
- Graphical, kinetic, and equilibrium analyses of in vivo [123I]β-CIT binding to dopamine transporters in healthy human subjects. J Cereb Blood Flow Metab. 1994;14:982–994
- Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. J Nucl Med. 2004;45:673–681
- . Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science. 1986;231:258–261
- Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab. 1993;13:24–42
- . PET brain imaging with [11C](+)McN5652 shows increased serotonin transporter availability in major depression. J Affect Disord. 2004;82:321–327
- Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans. J Nucl Med. 2004;45:682–694
- Regional distribution of serotonin transporter protein in postmortem human brain. Is the cerebellum a SERT-free brain region?. Nucl Med Biol. 2005;32:123–128
- Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory. Am J Psychiatry. 2003;160:334–340
- . Memory-related hippocampal dysfunction in poly-drug ecstasy (3,4-methylenedioxymethamphetamine) users. Psychopharmacology. 2004;[10.1007/s00213-004-2002-8]
- Comparison of (+)-11C-McN5652 and 11C-DASB as serotonin transporter radioligands under various experimental conditions. J Nucl Med. 2002;43:678–692
- . Positron and single photon emission tomography. Principles and application in psychopharmacology. In: Bloom FE, Kupfer DJ editor. Psychopharmacology: the fourth generation of progress. New York (NY): Raven Press; 1995;p. 865–879
- . Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography. [Review] Mol Imaging Biol. 2003;5:363–375
- Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson's disease. J Nucl Med. 1998;39:1879–1884
- Sex differences in [123I]β-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse. 2001;41:275–284
PII: S0969-8051(05)00263-5
doi: 10.1016/j.nucmedbio.2005.10.005
© 2006 Elsevier Inc. All rights reserved.
« Previous
Next »
Nuclear Medicine and Biology
Volume 33, Issue 2
, Pages 185-191
, February 2006
