Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 71-79 , January 2006

Reproducibility of intraperitoneal 2-deoxy-2-[18F]-fluoro-d-glucose cerebral uptake in rodents through time

  • Douglas A. Marsteller

      Affiliations

    • Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, Stony Brook, NY 11794-8651, USA
    • Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
    • Corresponding Author InformationCorresponding author. Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Tel.: +1 631 344 4393; fax: +1 631 344 5815.
  • ,
  • Nicole C. Barbarich-Marsteller

      Affiliations

    • Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
    • Graduate Program in Neuroscience, Department of Neurobiology and Behavior, SUNY Stony Brook, Stony Brook, NY 11794-5230, USA
  • ,
  • Joanna S. Fowler

      Affiliations

    • Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
  • ,
  • Wynne K. Schiffer

      Affiliations

    • Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
  • ,
  • David L. Alexoff

      Affiliations

    • Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
  • ,
  • Daniel J. Rubins

      Affiliations

    • Imaging Department, Merck Research Laboratories, West Point, PA 19486, USA
  • ,
  • Stephen L. Dewey

      Affiliations

    • Graduate Program in Molecular and Cellular Pharmacology, SUNY Stony Brook, Stony Brook, NY 11794-8651, USA
    • Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA
    • Graduate Program in Neuroscience, Department of Neurobiology and Behavior, SUNY Stony Brook, Stony Brook, NY 11794-5230, USA
    • Psychiatry Department, New York University School of Medicine, New York, NY 10016, USA

Received 4 August 2005 ,Revised 7 September 2005 ,Accepted 12 September 2005.

References 

  1. Reivich M, Kuhl D, Wolf A, Greenberg J, Phelps M, Ido T, et al. Measurement of local cerebral glucose metabolism in man with 18F-2-fluoro-2-deoxy-d-glucose. Acta Neurol Scand Suppl. 1977;64:190–191
  2. Brownell GL, Ackerman RH, Strauss HW, Elmaleh DR, Cochavi S, Alpert N, et al. Preliminary imaging results with 18F-2-fluoro-2-deoxy-d-glucose. J Comput Assist Tomogr. 1980;4:473–477
  3. Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME, Cherry SR. In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat Biotechnol. 2000;18:655–660
  4. Watanabe M, Uchida H, Okada H, Shimizu K, Satoh N, Yoshikawa E, et al. A high resolution PET for small animal studies. IEEE Trans Med Imag. 1992;11:577–580
  5. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28:897–916
  6. Moore TH, Osteen TL, Chatziioannou TF, Hovda DA, Cherry SR. Quantitative assessment of longitudinal metabolic changes in vivo after traumatic brain injury in the adult rat using FDG-microPET. J Cereb Blood Flow Metab. 2000;20:1492–1501
  7. Dittmar M, Spruss T, Schuierer G, Horn M. External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats. Stroke. 2003;34:2252–2257
  8. Liddell RP, Patel TH, Weiss CR, Lee DS, Matsuhashi T, Brown PR, et al. Endovascular model of rabbit hindlimb ischemia: a platform to evaluate therapeutic angiogenesis. J Vasc Interv Radiol. 2005;16:991–998
  9. Soncrant TT, Holloway HW, Stipetic M, Rapoport SI. Cerebral glucose utilization in rats is not altered by hindlimb restraint or by femoral artery and vein cannulation. J Cereb Blood Flow Metab. 1988;8:720–726
  10. Doyle P, Guillaume-Gentil C, Rohner-Jeanrenaud F, Jeanrenaud B. Effects of corticosterone administration on local cerebral glucose utilization of rats. Brain Res. 1994;645:225–230
  11. Lang CH. Stress induced by central cholinergic stimulation alters regional distribution of glucose uptake. Shock. 1994;1:36–42
  12. Inglis FM, Moghaddam B. Dopaminergic innervation of the amygdala is highly responsive to stress. J Neurochem. 1999;72:1088–1094
  13. Timmerman W, Cisci G, Nap A, de Vries JB, Westerink BH. Effects of handling on extracellular levels of glutamate and other amino acids in various areas of the brain measured by microdialysis. Brain Res. 1999;833:150–160
  14. Cenci MA, Kalen P. Serotonin release from mesencephalic raphe neurons grafted to the 5,7-dihydroxytryptamine-lesioned rat hippocampus: effects of behavioral activation and stress. Exp Neurol. 2000;164:351–361
  15. Del Arco A, Segovia G, Mora F. Dopamine release during stress in the prefrontal cortex of the rat decreases with age. Neuroreport. 2001;12:4019–4022
  16. Marsteller DA, Gerasimov MR, Schiffer WK, Geiger JM, Barnett CR, Borg JS, et al. Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex. Neuropsychopharmacology. 2002;27:163–170
  17. Gouzoulis-Mayfran E, Schreckenberger M, Sabri O, Arning C, Thelen B, Spitzer M, et al. Neurometabolic effects of psilocybin, 3,4-methylenedioxyethylamphetamine (MDE) and d-methamphetamine in healthy volunteers. A double-blind, placebo-controlled PET study with [18F]FDG. Neuropsychopharmacology. 1999;20:565–581
  18. Fowler JS, Volkow ND. 18FDG for the study of central nervous system drugs. J Clin Pharmacol. 2001;41:9S–10S
  19. Bartlett EJ, Brodie JD, Simkowitz P, Dewey SL, Lindenmayer J-P, Rusinek H, et al. Effect of a haloperidol challenge on regional brain metabolism in neuroleptic-responsive and nonresponsive schizophrenic patients. Am J Psychiatry. 1998;155:337–343
  20. Meibach RC, Glick SD, Ross DA, Cox RD, Maayani S. Intraperitoneal administration and other modifications of the 2-deoxy-d-glucose technique. Brain Res. 1980;195:167–176
  21. Kelly PA, McCulloch J. A potential error in modifications of the [14C]2-deoxyglucose technique. Brain Res. 1983;260:172–177
  22. Harris RB, Gu H, Mitchell TD, Endale L, Russo M, Ryan DH. Increased glucocorticoid response to a novel stress in rats that have been restrained. Physiol Behav. 2004;81:557–568
  23. Fowler JS, Gallagher BM, MacGregor RR, Wolf AP. Carbon-11 labeled aliphatic amines in lung uptake and metabolism studies: potential for dynamic measurements in vivo. J Pharmacol Exp Ther. 1976;198:133–145
  24. Toyama H, Ichise M, Liow J-S, Modell KJ, Vines DC, Esaki T, et al. Absolute quantification of regional cerebral glucose utilization in mice by 18f-FDG small animal PET scanning and 2-14C-DG autoradiography. J Nucl Med. 2004;45:1398–1405
  25. Hosoi R, Matsumura A, Mizokawa S, Tanaka M, Nakamura F, Kobayashi K, et al. MicroPET detection of enhanced 18F-FDG utilization by PKA inhibitor in awake rat brain. Brain Res. 2005;1039:199–202
  26. Hoffman EJ, Huang SC, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr. 1979;3:299–308
  27. Rubins DJ, Melega WP, Lacan G, Way B, Plenevaux A, Luxen A, et al. Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain. Neuroimage. 2003;20:2100–2118
  28. Gonzalez-Lima F. Brain imaging of auditory learning functions in rats: studies with fluorodeoxyglucose autoradiography and cytochrome oxidase histochemistry. In:  Gonzalez-Lima F,  Finkenstadt T,  Scheich H editor. Advances in metabolic mapping techniques for brain imaging of behavioral and learning functions. Boston: Kluwer Academic Publishers; 1992;p. 39–109
  29. Taylor JR. In:  Taylor JR editors. An introduction to error analysis. 2nd ed.. Sausalito: University Science Books; 1997;
  30. Bartlett EJ, Brodie JD, Wolf AP, Christman DR, Laska E, Meissner M. Reproducibility of cerebral glucose metabolic measurements in resting human subjects. J Cereb Blood Flow Metab. 1988;8:502–512
  31. Daniel PM, Love ER, Pratt OE. The effect of age upon the influx of glucose into the brain. J Physiol. 1978;274:141–148
  32. London ED, Nespor SM, Ohata M, Rapoport SI. Local cerebral glucose utilization during development and aging of the Fischer-344 rat. J Neurochem. 1981;37:217–221
  33. Smith CB, Goochee C, Rapoport SI, Sokoloff L. Effects of ageing on local rates of cerebral glucose utilization in the rat. Brain. 1980;103:351–365
  34. Huang SC. Anatomy of SUV. Standardized uptake value. Nucl Med Biol. 2000;27:643–646
  35. Moeller JR, Ishikawa T, Dhawan V, Spetsieris P, Mandel F, Alexander GE, et al. The metabolic topography of normal aging. J Cereb Blood Flow Metab. 1996;16:385–398
  36. Petit-Taboue MC, Landeau B, Desson JF, Desgranges B, Baron JC. Effects of healthy aging on the regional cerebral metabolic rate of glucose assessed with statistical parametric mapping. Neuroimage. 1998;7:176–184
  37. Willis MW, Ketter TA, Kimbrell TA, George MS, Herscovitch P, Danielson AL, et al. Age, sex and laterality effects on cerebral glucose metabolism in healthy adults. Psychiatry Res. 2002;114:23–37
  38. Fowler JS, Volkow ND, Wang GJ, Ding YS. 2-Deoxy-2-[18F]fluoro-d-glucose and alternative radiotracers for positron emission tomography imaging using the human brain as a model. Semin Nucl Med. 2004;34:112–121
  39. Volkow ND, Logan J, Fowler JS, Wang G-J, Gur RC, Wong C, et al. Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism. Am J Psychiatry. 2000;157:75–80
  40. De Santi S, de Leon MJ, Convit A, Tarshish C, Rusinek H, Tsui WH, et al. Age-related changes in brain: II. Positron emission tomography of frontal and temporal lobe glucose metabolism in normal subjects. Psychiatr Q. 1995;66:357–370
  41. Wang GJ, Volkow ND, Wolf AP, Brodie JD, Hitzemann RJ. Intersubject variability of brain glucose metabolic measurements in young normal males. J Nucl Med. 1994;35:1457–1466
  42. Lee JS, Lee DS, Park KS, Chung J-K, Lee MC. Changes in the heterogeneity of cerebral glucose metabolism with healthy aging: quantitative assessment by fractal analysis. J Neuroimaging. 2004;14:350–356
  43. Kuhl DE, Metter EJ, Riege WH, Phelps ME. Effects of human aging on patterns of local cerebral glucose utilization determined by the [18F]fluorodeoxyglucose method. J Cereb Blood Flow Metab. 1982;2:163–171
  44. McGeer EG, Peppard RP, McGeer PL, Tuokko H, Crockett D, Parks R, et al. 18Fluorodeoxyglucose positron emission tomography studies in presumed Alzheimer cases, including 13 serial scans. Can J Neurol Sci. 1990;17:1–11
  45. de Leon MJ, George AE, Tomanelli J, Christman D, Kluger A, Miller J, et al. Positron emission tomography studies of normal aging: a replication of PET III and 18-FDG using PET VI and 11-CDG. Neurobiol Aging. 1987;8:319–323
  46. Duara R, Margolin RA, Robertson-Tchabo EA, London ED, Schwartz M, Renfrew JW, et al. Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. Brain. 1983;106:761–775
  47. Rapoport SI. Positron emission tomography in normal aging and Alzheimer's disease. Gerontology. 1986;32(Suppl 1):6–13
  48. Salmon E, Maquet P, Sadzot B, Degueldre C, Lemaire C, Franck G. Decrease of frontal metabolism demonstrated by positron emission tomography in a population of healthy elderly volunteers. Acta Neurol Belg. 1991;91:288–295
  49. Gage FH, Kelly PA, Bjorklund A. Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats. J Neurosci. 1984;4:2856–2865
  50. Larrabee GJ, Crook TH. Estimated prevalence of age-associated memory impairment derived from standardized tests of memory function. Int Psychogeriatr. 1994;6:95–104
  51. de Leon MJ, Convit A, Wolf OT, Tarshish CY, DeSanti S, Rusinek H, et al. Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-d-glucose/positron-emission tomography (FDG/PET). PNAS. 2001;98:10966–10971
  52. Schiffer W, Mirrione M, Biegon A, Alexoff D, Patel V, Dewey S. Serial microPET measures of the metabolic reaction to a microdialysis probe implant. J Neurosci Methods. 2005;144:25–34
  53. Eberling JL, Roberts JA, Rapp PR, Tuszynski MH, Jagust WJ. Cerebral glucose metabolism and memory in aged rhesus macaques. Neurobiol Aging. 1997;18:437–443
  54. Nehlig A, Porrino LJ, Crane AM, Sokoloff L. Local cerebral glucose utilization in normal female rats: variations during the estrous cycle and comparison with males. J Cereb Blood Flow Metab. 1985;5:393–400
  55. Brown LL, Siegel H, Etgen AM. Global sex differences in stress-induced activation of cerebral metabolism revealed by 2-deoxyglucose autoradiography. Horm Behav. 1996;30:611–617
  56. Andreason PJ, Zametkin AJ, Guo AC, Baldwin P, Cohen RM. Gender-related differences in regional cerebral glucose metabolism in normal volunteers. Psychiatry Res. 1994;51:175–183
  57. Baxter LR, Mazziotta JC, Phelps ME, Selin CE, Guze BH, Fairbanks L. Cerebral glucose metabolic rates in normal human females versus normal males. Psychiatry Res. 1987;21:237–245
  58. Fallon JH, Keator DB, Mbogori J, Taylor D, Potkin SG. Gender: a major determinant of brain response to nicotine. Int J Neuropsychopharmacol. 2005;8:17–26
  59. Yoshii F, Barker WW, Chang JY, Loewenstein D, Apicella A, Smith D, et al. Sensitivity of cerebral glucose metabolism to age, gender, brain volume, brain atrophy, and cerebrovascular risk factors. J Cereb Blood Flow Metab. 1988;8:654–661
  60. Schmidt ME, Matochik JA, Goldstein DS, Schouten JL, Zametkin AJ, Potter WZ. Gender differences in brain metabolic and plasma catecholamine responses to alpha 2-adrenoceptor blockade. Neuropsychopharmacology. 1997;16:298–310
  61. Nickel J, Jokeit H, Wunderlich G, Ebner A, Witte OW, Seitz RJ. Gender-specific differences of hypometabolism in mTLE: implication for cognitive impairments. Epilepsia. 2003;44:1551–1561
  62. Gur R, Mozley L, Mozley P, Resnick S, Karp J, Alavi A, et al. Sex differences in regional cerebral glucose metabolism during a resting state. Science. 1995;267:528–531
  63. Kawachi T, Ishii K, Sakamoto S, Matsui M, Mori T, Sasaki M. Gender differences in cerebral glucose metabolism: a PET study. J Neurol Sci. 2002;199:79–83
  64. Miura SA, Schapiro MB, Grady CL, Kumar A, Salerno JA, Kozachuk WE, et al. Effect of gender on glucose utilization rates in healthy humans: a positron emission tomography study. J Neurosci Res. 1990;27:500–504
  65. Barbarich-Marsteller NC, Marsteller DA, Alexoff DL, Fowler JS, Dewey SL. MicroPET imaging in an animal model of anorexia nervosa. Synapse. 2005;57:85–90

PII: S0969-8051(05)00212-X

doi: 10.1016/j.nucmedbio.2005.09.003

Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 71-79 , January 2006