Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 43-52 , January 2006

Polymer-peptide conjugates for angiogenesis targeted tumor radiotherapy

  • Amitava Mitra

      Affiliations

    • Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA
    • Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201, USA
    • ,
  • Anjan Nan

      Affiliations

    • Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA
    • Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201, USA
    • ,
  • John C. Papadimitriou

      Affiliations

    • Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    • ,
  • Hamidreza Ghandehari

      Affiliations

    • Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA
    • Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201, USA
    • Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    • Corresponding Author InformationCorresponding authors. Bruce R. Line is to be contacted at Division of Nuclear Medicine, Department of Radiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Tel.: +1 410 328 6888; fax: +1 410 328 1600. Hamidreza Ghandehari, Department of Pharmaceutical Sciences, Center for Nanomedicine and Cellular Delivery, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA. Tel.: +1 410 706 8650; fax: +1 410 706 5017.
    • ,
  • Bruce R. Line

      Affiliations

    • Center for Nanomedicine and Cellular Delivery, University of Maryland, Baltimore, MD 21201, USA
    • Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    • Division of Nuclear Medicine, Department of Radiology, University of Maryland, Baltimore, MD 21201, USA
    • Corresponding Author InformationCorresponding authors. Bruce R. Line is to be contacted at Division of Nuclear Medicine, Department of Radiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Tel.: +1 410 328 6888; fax: +1 410 328 1600. Hamidreza Ghandehari, Department of Pharmaceutical Sciences, Center for Nanomedicine and Cellular Delivery, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA. Tel.: +1 410 706 8650; fax: +1 410 706 5017.

Received 29 July 2005 ,Revised 7 September 2005 ,Accepted 12 September 2005.

References 

  1. Jain RK. Barriers to drug delivery in solid tumors. Sci Am. 1994;271(1):58–65
  2. Jain RK, Munn LL, Fukumura D. Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer. 2002;2(4):266–276
  3. Los M, Voest EE. The potential role of antivascular therapy in the adjuvant and neoadjuvant treatment of cancer. Semin Oncol. 2001;28(1):93–105
  4. Denekamp J. Review article: angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy. Br J Radiol. 1993;66(783):181–196
  5. Neri D, Bicknell R. Tumor vascular targeting. Nat Rev Cancer. 2005;5:436–446
  6. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249–257
  7. Brekken RA, Thorpe PE. Vascular endothelial growth factor and vascular targeting of solid tumors. Anticancer Res. 2001;21(6B):4221–4229
  8. Ellis LM, Liu W, Fan F, Jung YD, Reinmuth N, Stoeltzing O, et al. Synopsis of angiogenesis inhibitors in oncology. Oncology (Huntington). 2002;16(5 Suppl 4):14–22
  9. Folkman J, Shing Y. Angiogenesis. J Biol Chem. 1992;267(16):10931–10934
  10. Tozer GM, Kanthou C, Baguley BC. Disrupting tumor blood vessels. Nat Rev Cancer. 2005;5:423–435
  11. Kopecek J, Kopeckova P, Minko T, Lu Z. HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action. Eur J Pharm Biopharm. 2000;50(1):61–81
  12. Strohalm J, Kopecek J. Poly N-(2-hydroxypropyl) methacrylamide: 4. Heterogeneous polymerization. Angew Makromol Chem. 1978;70:109–118
  13. Rejmanova P, Labsky J, Kopecek J. Aminolyses of monomeric and polymeric p-nitrophenyl esters of methacryloylated amino acids. Makromol Chem. 1977;178:2159–2168
  14. Mitra A, Nan A, Ghandehari H, McNeill E, Mulholland J, Line BR. Technetium-99m-labeled N-(2-hydroxypropyl) methacrylamide copolymers: synthesis, characterization, and in vivo biodistribution. Pharm Res. 2004;21(7):1153–1159
  15. Lee JH, Kopeckova P, Kopecek J, Andrade JD. Surface properties of copolymers of alkyl methacrylates with methoxy (polyethylene oxide) methacrylates and their application as protein-resistant coatings. Biomaterials. 1990;11(7):455–464
  16. Yeh PY, Kopeckova P, Kopecek J. Biodegradable and pH sensitive hydrogels: synthesis by crosslinking of N,N-dimethylacrylamide copolymer precursors. J Polym Sci A Polym Chem. 1994;32:1627–1637
  17. Mitra A, Mulholland J, Nan A, McNeill E, Ghandehari H, Line BR. Targeting tumor angiogenic vasculature using polymer-RGD conjugates. J Control Release. 2005;102(1):191–201
  18. Camera L, Kinuya S, Garmestani K, Wu C, Brechbiel MW, Pai LH, et al. Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies. J Nucl Med. 1994;35(5):882–889
  19. Ruoslahti E. Specialization of tumour vasculature. Nat Rev Cancer. 2002;2(2):83–90
  20. Pedley RB, Hill SA, Boxer GM, Flynn AA, Boden R, Watson R, et al. Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate. Cancer Res. 2001;61(12):4716–4722
  21. Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer. 2002;2(10):727–739
  22. Jain RK. The next frontier of molecular medicine: delivery of therapeutics. Nat Med. 1998;4(6):655–657
  23. Goldenberg DM. Targeted therapy of cancer with radiolabeled antibodies. J Nucl Med. 2002;43(5):693–713
  24. Shiah JJ, Sun Y, Peterson CM, Kopecek J. Biodistribution of free and N-(2-hydroxypropyl)methacrylamide copolymer-bound mesochlorin e(6) and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts. J Control Release. 1999;61(1–2):145–157
  25. Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov. 2003;2(5):347–360
  26. Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release. 2000;65(1–2):271–284
  27. Satchi-Fainaro R, Puder M, Davies JW, Tran HT, Sampson DA, Greene AK, et al. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nat Med. 2004;10(3):255–261
  28. Lu ZR, Shiah JG, Sakuma S, Kopeckova P, Kopecek J. Design of novel bioconjugates for targeted drug delivery. J Control Release. 2002;78(1–3):165–173
  29. Line BR, Mitra A, Nan A, Ghandehari H. Targeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates. J Nucl Med. 2005;46(9):1552–1560
  30. Koivunen E, Wang B, Ruoslahti E. Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins. Biotechnology (NY). 1995;13(3):265–270
  31. van der FA, Sonnenberg A. Function and interactions of integrins. Cell Tissue Res. 2001;305(3):285–298
  32. Seymour LW, Duncan R, Strohalm J, Kopecek J. Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats. J Biomed Mater Res. 1987;21(11):1341–1358
  33. Seymour LW, Miyamoto Y, Maeda H, Brereton M, Strohalm J, Ulbrich K, et al. Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur J Cancer. 1995;31A(5):766–770
  34. Kissel M, Peschke P, Subr V, Ulbrich K, Schuhmacher J, Debus J, et al. Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors. PDA J Pharm Sci Technol. 2001;55(3):191–201
  35. Kissel M, Peschke P, Subr V, Ulbrich K, Schuhmacher J, Debus J, et al. Biodistribution of charged poly(N-2-(hydroxy-propyl)-methacrylamide) in tumor bearing rats. 28th Proc Intl Symp Control Rel Bioact Mater. 2001;1346–1347
  36. Press OW, Rasey J. Principles of radioimmunotherapy for hematologists and oncologists. Semin Oncol. 2000;27(6 Suppl 12):62–73

PII: S0969-8051(05)00209-X

doi: 10.1016/j.nucmedbio.2005.09.005

Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 43-52 , January 2006

Article Tools

* Image Usage & Resolution