Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 65-70 , January 2006

Animal-specific positioning molds for registration of repeat imaging studies: comparative microPET imaging of F18-labeled fluoro-deoxyglucose and fluoro-misonidazole in rodent tumors

  • Pat Zanzonico

      Affiliations

    • Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 639 2487; fax: +1 212 717 3442.
    • ,
  • Jose Campa

      Affiliations

    • Nuclear Medicine Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    • ,
  • Dolores Polycarpe-Holman

      Affiliations

    • Nuclear Medicine Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    • ,
  • Gregor Forster

      Affiliations

    • Nuclear Medicine Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    • ,
  • Ronald Finn

      Affiliations

    • Cyclotron and Radiochemistry Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    • ,
  • Steven Larson

      Affiliations

    • Nuclear Medicine Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    • ,
  • John Humm

      Affiliations

    • Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    • ,
  • Clifton Ling

      Affiliations

    • Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA

Received 22 June 2005 ,Revised 28 July 2005 ,Accepted 30 July 2005.

References 

  1. Chatziioannou AF. PET scanners dedicated to molecular imaging of small animal models. Mol Imaging Biol. 2002;4:47–63
  2. Herschman HR. Micro-PET imaging and small animal models of disease. Curr Opin Immunol. 2003;15:378–384
  3. Myers R. The biological application of small animal PET imaging. Nucl Med Biol. 2001;28:585–593
  4. Tornai MP, Jaszczak RJ, Turkington TG, Coleman RE. Small-animal PET: advent of a new era of PET research. J Nucl Med. 1999;40:1176–1179
  5. Zanzonico P. Positron emission tomography: a review of basic principles, scanner design and performance, and current systems. Semin Nucl Med. 2004;34:87–111
  6. Humm JL, Ballon D, Hu YC, et al. A stereotactic method for the three-dimensional registration of multi-modality biologic images in animals: NMR, PET, histology, and autoradiography. Med Phys. 2003;30:2303–2314
  7. Hutton BF, Braun M. Software for image registration: algorithms, accuracy, efficacy. Semin Nucl Med. 2003;33:180–192
  8. Hutton BF, Braun M, Thurfjell L, Lau DY. Image registration: an essential tool for nuclear medicine. Eur J Nucl Med Mol Imaging. 2002;29:559–577
  9. Pluim JP, Maintz JB, Viergever MA. Image registration by maximization of combined mutual information and gradient information. IEEE Trans Med Imaging. 2000;19:809–814
  10. Pluim JP, Maintz JB, Viergever MA. Mutual-information-based registration of medical images: a survey. IEEE Trans Med Imaging. 2003;22:986–1004
  11. Maes F, Collignon A, Vandermeulen D, Marchal G, Suetens P. Multimodality image registration by maximization of mutual information. IEEE Trans Med Imaging. 1997;16:187–198
  12. Chapman JD, Engelhardt EL, Stobbe CC, Schneider RF, Hanks GE. Measuring hypoxia and predicting tumor radioresistance with nuclear medicine assays. Radiother Oncol. 1998;46:229–237
  13. Chapman JD, Zanzonico P, Ling CC. On measuring mypoxia in individual tumors with radiolabeled agents. J Nucl Med. 2001;42:1653–1655
  14. Rasey JS, Koh WJ, Evans ML, et al. Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: a pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys. 1996;36:417–428
  15. Rasey JS, Koh WJ, Grierson JR, Grunbaum Z, Krohn KA. Radiolabelled fluoromisonidazole as an imaging agent for tumor hypoxia. Int J Radiat Oncol Biol Phys. 1989;17:985–991
  16. Cherif A, Yang DJ, Tansey W, Kim EE, Wallace S. Rapid synthesis of 3-[18F]fluoro-1-2-(2′-nitro-imidazolyl)-2-propranol([18F]fluoromisonidazole). Pharm Res. 1994;11:466–469
  17. Chatziioannou AF, Cherry SR, Shao Y, et al. Performance evaluation of microPET: a high-resolution lutetium oxyorthosilicate PET scanner for animal imaging. J Nucl Med. 1999;40:1164–1175
  18. Cherry SR, Shao Y, Silverman RW, et al. MicroPET: a high resolution PET scanner for imaging small animals. IEEE Trans Nucl Sci. 1997;NS-44:1161–1166
  19. O'Donoghue JA, Zanzonico P, Pugachev A, et al. Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models. Int J Radiat Oncol Biol Phys. 2005;61:1493–1502
  20. Wen B, Burgman P, Zanzonico P, et al. A preclinical model for noninvasive imaging of hypoxia-induced gene expression; comparison with an exogenous marker of tumor hypoxia. Eur J Nucl Med Mol Imaging. 2004;31:1530–1538
  21. Zanzonico P, O'Donoghue J, Chapman JD, et al. Iodine-124-labeled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanning. Eur J Nucl Med Mol Imaging. 2004;31:117–128
  22. Coleman R. Clinical PET in oncology. Clin Positron Imaging. 1998;1:15–30
  23. Schoder H, Erdi Y, Larson S, et al. PET/CT: a new imaging technology in nuclear medicine. Eur J Nucl Med Mol. 2003;30:1419–1437
  24. Bentzen L, Keiding S, Horsman MR, Falborg L, Hansen SB, Overgaard J. Feasibility of detecting hypoxia in experimental mouse tumours with 18F-fluorinated tracers and positron emission tomography-a study evaluating [18F]fluoro-2-deoxy-d-glucose. Acta Oncol. 2000;39:629–637
  25. Burgman P, Odonoghue JA, Humm JL, Ling CC. Hypoxia-induced increase in FDG uptake in MCF7 cells. J Nucl Med. 2001;42:170–175
  26. Clavo AC, Brown RS, Wahl RL. Fluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxia. J Nucl Med. 1995;36:1625–1632
  27. Rajendran JG, Mankoff DA, O'Sullivan F, et al. Hypoxia and glucose metabolism in malignant tumors: evaluation by [18F]fluoromisonidazole and [18F]fluorodeoxyglucose positron emission tomography imaging. Clin Cancer Res. 2004;10:2245–2252
  28. Rajendran JG, Wilson DC, Conrad EU, et al. [(18)F]FMISO and [(18)F]FDG PET imaging in soft tissue sarcomas: correlation of hypoxia, metabolism and VEGF expression. Eur J Nucl Med Mol Imaging. 2003;30:695–704

PII: S0969-8051(05)00199-X

doi: 10.1016/j.nucmedbio.2005.07.011

Nuclear Medicine and Biology
Volume 33, Issue 1 , Pages 65-70 , January 2006

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