Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 249-254 , February 2006

Change of central cholinergic receptors following lesions of nucleus basalis magnocellularis in rats: search for an imaging index suitable for the early detection of Alzheimer's disease

  • Mikako Ogawa

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
    • Photon Medical Research Center, Hamamatsu Medical University, Hamamatsu, Shizuoka 431-3192, Japan
  • ,
  • Yasuhiko Iida

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
    • School of Medicine, Gunma University, Maebashi, Gunma 371-8511, Japan
  • ,
  • Masaki Nakagawa

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
  • ,
  • Yugi Kuge

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
  • ,
  • Hidekazu Kawashima

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
  • ,
  • Akiko Tominaga

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
  • ,
  • Masashi Ueda

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
  • ,
  • Yasuhiro Magata

      Affiliations

    • Photon Medical Research Center, Hamamatsu Medical University, Hamamatsu, Shizuoka 431-3192, Japan
  • ,
  • Hideo Saji

      Affiliations

    • Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 75 753 4556; fax: +81 75 753 4568.

Received 10 March 2005 ,Revised 5 June 2005 ,Accepted 6 June 2005.

References 

  1. Faulstich ME. Brain imaging in dementia of the Alzheimer type. Int J Neurosci. 1991;57:39–49
  2. Demetriades AK. Functional neuroimaging in Alzheimer's type dementia. J Neurol Sci. 2002;203–204:247–251
  3. Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol. 1981;10:122–126
  4. Chefer SI, Horti AG, Lee KS, Koren AO, Jones DW, Gorey JG, et al. In vivo imaging of brain nicotinic acetylcholine receptors with 5-[123I]iodo-A-85380 using single photon emission computed tomography. Life Sci. 1998;63:L355–L360
  5. Horti AG, Scheffel U, Koren AO, Ravert HT, Mathews WB, Musachio JL, et al. 2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors. Nucl Med Biol. 1998;25:599–603
  6. Irie T, Fukushi K, Namba H, Iyo M, Tamagami H, Nagatsuka S, et al. Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease. J Nucl Med. 1996;37:649–655
  7. Saji H, Ogawa M, Ueda M, Iida Y, Magata Y, Tominaga A, et al. Evaluation of radioiodinated 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine as a ligand for SPECT investigations of brain nicotinic acetylcholine receptors. Ann Nucl Med. 2002;16:189–200
  8. Ding YS, Fowler JS, Logan J, Wang GJ, Telang F, Garza V, et al. 6-[18F]Fluoro-A-85380, a new PET tracer for the nicotinic acetylcholine receptor: studies in the human brain and in vivo demonstration of specific binding in white matter. Synapse. 2004;53:184–189
  9. Carson RE, Kiesewetter DO, Jagoda E, Der MG, Herscovitch P, Eckelman WC. Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies. J Cereb Blood Flow Metab. 1998;18:1130–1142
  10. Zubieta JK, Koeppe RA, Frey KA, Kilbourn MR, Mangner TJ, Foster NL, et al. Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [11C]NMPB and PET. Synapse. 2001;39:275–287
  11. Hamacher K, Coenen HH, Stocklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986;27:235–238
  12. Sokoloff L, Reivich M, Kennedy C, Des M, Rosiers H, Patlak CS, et al. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem. 1977;28:897–916
  13. Haba K, Ogawa N, Kawata M, Mori A. A method for parallel determination of choline acetyltransferase and muscarinic cholinergic receptors: application in aged-rat brain. Neurochem Res. 1988;13:951–955
  14. Yamamura HI, Snyder SH. Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci U S A. 1974;71:1725–1729
  15. Pabreza LA, Dhawan S, Kellar KJ. [3H]Cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol. 1991;39:9–12
  16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265–275
  17. Moyse E, Szigethy E, Danger JM, Vaudry H, Wenk GL, Beaudet A, et al. Short- and long-term effects of nucleus basalis magnocellularis lesions on cortical levels of somatostatin and its receptors in the rat. Brain Res. 1993;607:154–160
  18. Calaminici M, Abdulla FA, Sinden JD, Stephenson JD. Plastic changes in the cholinergic innervation of the rat cerebral cortex after unilateral lesion of the nucleus basalis with alpha-amino-3-OH-4-isoxozole propionic acid (AMPA): effects of basal forebrain transplants into neocortex. Brain Res Bull. 1997;42:79–93
  19. London ED, McKinney M, Dam M, Ellis A, Coyle JT. Decreased cortical glucose utilization after ibotenate lesion of the rat ventromedial globus pallidus. J Cereb Blood Flow Metab. 1984;4:381–390
  20. Kiyosawa M, Pappata S, Duverger D, Riche D, Cambon H, Mazoyer B, et al. Cortical hypometabolism and its recovery following nucleus basalis lesions in baboons: a PET study. J Cereb Blood Flow Metab. 1987;7:812–817
  21. Kiyosawa M, Baron JC, Hamel E, Pappata S, Duverger D, Riche D, et al. Time course of effects of unilateral lesions of the nucleus basalis of Meynert on glucose utilization by the cerebral cortex. Positron tomography in baboons. Brain. 1989;112:435–455
  22. Katsumi Y, Hayashi T, Oyanagi C, Nagahama Y, Yamauchi H, Ono S, et al. Glucose metabolism in the rat frontal cortex recovered without the recovery of choline acetyltransferase activity after lesioning of the nucleus basalis magnocellularis. Neurosci Lett. 2000;280:9–12
  23. Abdulla FA, Calaminici M, Wonnacott S, Gray JA, Sinden JD, Stephenson JD. Sensitivity of rat frontal cortical neurones to nicotine is increased by chronic administration of nicotine and by lesions of the nucleus basalis magnocellularis: comparison with numbers of [3H]nicotine binding sites. Synapse. 1995;21:281–288
  24. Bednar I, Zhang X, Dastranj-Sedghi R, Nordberg A. Differential changes of nicotinic receptors in the rat brain following ibotenic acid and 192-IgG saporin lesions of the nucleus basalis magnocellularis. Int J Dev Neurosci. 1998;16:661–668
  25. Wenk GL, Rokaeus A. Basal forebrain lesions differentially alter galanin levels and acetylcholinergic receptors in the hippocampus and neocortex. Brain Res. 1988;460:17–21
  26. Miyai I, Ueno S, Yorifuji S, Fujimura H, Tarui S. Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis. J Neural Transm Gen Sect. 1990;82:79–91
  27. Rossner S, Schliebs R, Perez-Polo JR, Wiley RG, Bigl V. Differential changes in cholinergic markers from selected brain regions after specific immunolesion of the rat cholinergic basal forebrain system. J Neurosci Res. 1995;40:31–43
  28. Watson M, Vickroy TW, Fibiger HC, Roeske WR, Yamamura HI. Effects of bilateral ibotenate-induced lesions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex. Brain Res. 1985;346:387–391
  29. Katayama S, Kito S, Yamamura Y. Increase of muscarinic receptor following kainic acid lesions of the nucleus basalis magnocellularis in rat brain: an autoradiographic study. Res Commun Chem Pathol Pharmacol. 1990;68:391–394
  30. Raulli RE, Arendash G, Crews FT. Effects of nBM lesions on muscarinic-stimulation of phosphoinositide hydrolysis. Neurobiol Aging. 1989;10:191–197
  31. Sorger D, Kampfer I, Schliebs R, Rossner S, Dannenberg C, Knapp WH. Iodo-QNB cortical binding and brain perfusion: effects of a cholinergic basal forebrain lesion in the rat. Nucl Med Biol. 1999;26:9–16
  32. Scheffel U, Horti AG, Koren AO, Ravert HT, Banta JP, Finley PA, et al. 6-[18F]Fluoro-A-85380: an in vivo tracer for the nicotinic acetylcholine receptor. Nucl Med Biol. 2000;27:51–56
  33. Fujita M, Ichise M, van Dyck CH, Zoghbi SS, Tamagnan G, Mukhin AG, et al. Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET. Eur J Nucl Med Mol Imaging. 2003;30:1620–1629
  34. Kimes AS, Horti AG, London ED, Chefer SI, Contoreggi C, Ernst M, et al. 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. Faseb J. 2003;17:1331–1333
  35. Mamede M, Ishizu K, Ueda M, Mukai T, Iida Y, Fukuyama H, et al. Quantification of human nicotinic acetylcholine receptors with 123I-5IA SPECT. J Nucl Med. 2004;45:1458–1470

PII: S0969-8051(05)00156-3

doi: 10.1016/j.nucmedbio.2005.06.013

Nuclear Medicine and Biology
Volume 33, Issue 2 , Pages 249-254 , February 2006